Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease.

Jana A, Pahan K. Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease. J Biol Chem. 2004 Dec 03; 279(49):51451-9.

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subject areas

Alzheimer Disease
Amyloid beta-Peptides
Apoptosis
Cell Survival
Cells, Cultured
Ceramides
Diacylglycerol Kinase
DNA
Enzyme Activation
Humans
Hydrogen Peroxide
Hypoxanthine
In Situ Nick-End Labeling
Lipids
Membrane Transport Proteins
NADPH Dehydrogenase
Neurons
Oligonucleotides, Antisense
Oxidation-Reduction
Oxygen
Peptide Fragments
Peptides
Phosphoproteins
Reactive Oxygen Species
Sphingomyelin Phosphodiesterase
Superoxides
Time Factors
Xanthine Oxidase

authors with profiles

Kalipada Pahan