Complement Pathway, Classical
"Complement Pathway, Classical" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
Descriptor ID |
D003171
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MeSH Number(s) |
G12.274.698
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Concept/Terms |
Complement Pathway, Classical- Complement Pathway, Classical
- Classical Complement Activation Pathway
- Complement Activation Pathway, Classical
- Classical Complement Pathway
|
Below are MeSH descriptors whose meaning is more general than "Complement Pathway, Classical".
Below are MeSH descriptors whose meaning is more specific than "Complement Pathway, Classical".
This graph shows the total number of publications written about "Complement Pathway, Classical" by people in this website by year, and whether "Complement Pathway, Classical" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 1 | 1 |
1996 | 1 | 0 | 1 |
1999 | 1 | 0 | 1 |
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Below are the most recent publications written about "Complement Pathway, Classical" by people in Profiles.
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Human antibodies to major histocompatibility complex alloantigens mediate lysis and neutralization of HIV-1 primary isolate virions in the presence of complement. J Acquir Immune Defic Syndr. 2001 Feb 01; 26(2):103-10.
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Alteration of complement protein levels after antiretroviral therapy in HIV-infected persons. AIDS Res Hum Retroviruses. 1999 Dec 10; 15(18):1713-5.
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Susceptibility of HIV-1 plasma virus to complement-mediated lysis. Evidence for a role in clearance of virus in vivo. J Immunol. 1996 Aug 15; 157(4):1791-8.
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Decreased levels of complement receptor 1 (CD35) on B lymphocytes in persons with HIV infection. Clin Immunol Immunopathol. 1995 Apr; 75(1):20-5.
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Human immunodeficiency virus (HIV)-infected cells and free virus directly activate the classical complement pathway in rabbit, mouse and guinea-pig sera; activation results in virus neutralization by virolysis. Immunology. 1991 Aug; 73(4):377-82.
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Activation of complement on the surface of cells infected by human immunodeficiency virus. J Immunol. 1990 Feb 15; 144(4):1490-6.