Studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.

Descriptor ID	D017321
MeSH Number(s)	E05.318.760.535.200 E05.337.250.200 N05.715.360.775.235.200 N06.850.520.450.535.200
Concept/Terms	Clinical Trials, Phase I as Topic Clinical Trials, Phase I as Topic Phase 1 Clinical Trials Clinical Trials, Phase 1 Phase I Clinical Trials Clinical Trials, Phase I Evaluation Studies, FDA Phase I Evaluation Studies, FDA Phase I Evaluation Studies, FDA Phase 1 Microdosing Trials, Human Microdosing Trials, Human Human Microdosing Trial Microdosing Trial, Human Trial, Human Microdosing Trials, Human Microdosing Human Microdosing Trials Drug Evaluation, FDA Phase I as Topic Drug Evaluation, FDA Phase I as Topic Drug Evaluation, FDA Phase I Drug Evaluation, FDA Phase 1

Below are MeSH descriptors whose meaning is more general than "Clinical Trials, Phase I as Topic".

Below are MeSH descriptors whose meaning is related to "Clinical Trials, Phase I as Topic".

Below are MeSH descriptors whose meaning is more specific than "Clinical Trials, Phase I as Topic".