 Arachidonate 12-Lipoxygenase
"Arachidonate 12-Lipoxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.
| Descriptor ID |
D001092
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| MeSH Number(s) |
D08.811.682.690.416.583.500.060 D12.776.556.579.374.568.500.025
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| Concept/Terms |
Arachidonate 12-Lipoxygenase- Arachidonate 12-Lipoxygenase
- 12-Lipoxygenase, Arachidonate
- Arachidonate 12 Lipoxygenase
- Arachidonic Acid 12-Lipoxygenase
- 12-Lipoxygenase, Arachidonic Acid
- Arachidonic Acid 12 Lipoxygenase
- 12-Lipoxygenase
- 12 Lipoxygenase
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Below are MeSH descriptors whose meaning is more general than "Arachidonate 12-Lipoxygenase".
Below are MeSH descriptors whose meaning is more specific than "Arachidonate 12-Lipoxygenase".
This graph shows the total number of publications written about "Arachidonate 12-Lipoxygenase" by people in this website by year, and whether "Arachidonate 12-Lipoxygenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Arachidonate 12-Lipoxygenase" by people in Profiles.
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Lindley AR, Crapster-Pregont M, Liu Y, Kuperman DA. 12/15-lipoxygenase is an interleukin-13 and interferon-? counterregulated-mediator of allergic airway inflammation. Mediators Inflamm. 2010; 2010.
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Hajek AR, Lindley AR, Favoreto S, Carter R, Schleimer RP, Kuperman DA. 12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels. J Allergy Clin Immunol. 2008 Sep; 122(3):633-9.e3.
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Hong SH, Avis I, Vos MD, MartÃnez A, Treston AM, Mulshine JL. Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors. Cancer Res. 1999 May 01; 59(9):2223-8.
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