 DNA-Directed DNA Polymerase
"DNA-Directed DNA Polymerase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
| Descriptor ID |
D004259
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| MeSH Number(s) |
D08.811.913.696.445.308.300
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| Concept/Terms |
DNA-Directed DNA Polymerase- DNA-Directed DNA Polymerase
- DNA Directed DNA Polymerase
- DNA Polymerase, DNA-Directed
- Polymerase, DNA-Directed DNA
- DNA-Dependent DNA Polymerases
- DNA Dependent DNA Polymerases
- DNA Polymerases, DNA-Dependent
- Polymerases, DNA-Dependent DNA
- DNA Polymerases
- Polymerases, DNA
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Below are MeSH descriptors whose meaning is more general than "DNA-Directed DNA Polymerase".
Below are MeSH descriptors whose meaning is more specific than "DNA-Directed DNA Polymerase".
This graph shows the total number of publications written about "DNA-Directed DNA Polymerase" by people in this website by year, and whether "DNA-Directed DNA Polymerase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 1 | 0 | 1 | | 1999 | 1 | 1 | 2 | | 2002 | 0 | 1 | 1 | | 2003 | 1 | 1 | 2 | | 2004 | 0 | 2 | 2 | | 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA-Directed DNA Polymerase" by people in Profiles.
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Lurain NS, Chou S. Antiviral drug resistance of human cytomegalovirus. Clin Microbiol Rev. 2010 Oct; 23(4):689-712.
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Blackman SC, Lurain NS, Witte DP, Filipovich AH, Groen P, Schleiss MR. Emergence and compartmentalization of fatal multi-drug-resistant cytomegalovirus infection in a patient with autosomal-recessive severe combined immune deficiency. J Pediatr Hematol Oncol. 2004 Sep; 26(9):601-5.
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Baldanti F, Lurain N, Gerna G. Clinical and biologic aspects of human cytomegalovirus resistance to antiviral drugs. Hum Immunol. 2004 May; 65(5):403-9.
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Chou S, Lurain NS, Thompson KD, Miner RC, Drew WL. Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. J Infect Dis. 2003 Jul 01; 188(1):32-9.
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Weinberg A, Jabs DA, Chou S, Martin BK, Lurain NS, Forman MS, Crumpacker C. Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis. J Infect Dis. 2003 Mar 01; 187(5):777-84.
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Shafikhani S. Factors affecting PCR-mediated recombination. Environ Microbiol. 2002 Aug; 4(8):482-6.
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Waldman WJ, Knight DA, Lurain NS, Miller DM, Sedmak DD, Williams JW, Chong AS. Novel mechanism of inhibition of cytomegalovirus by the experimental immunosuppressive agent leflunomide. Transplantation. 1999 Sep 27; 68(6):814-25.
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Chou S, Lurain NS, Weinberg A, Cai GY, Sharma PL, Crumpacker CS. Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance. Adult AIDS Clinical Trials Group CMV Laboratories. Antimicrob Agents Chemother. 1999 Jun; 43(6):1500-2.
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Lurain NS, Thompson KD, Holmes EW, Read GS. Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents. J Virol. 1992 Dec; 66(12):7146-52.
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